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Article

Nuclear mRNA quality control in yeast is mediated by Nrd1 co-transcriptional recruitment, as revealed by the targeting of Rho-induced aberrant transcripts.

Nucleic acids research - 1 Apr 2011

Honorine Romy, Mosrin-Huaman Christine, Hervouet-Coste Nadège, Libri Domenico, Rahmouni A Rachid

Abstract excerpt

The production of mature export-competent transcripts is under the surveillance of quality control steps where aberrant mRNP molecules resulting from inappropriate or inefficient processing and packaging reactions are subject to exosome-mediated degradation. Previously, we have shown that the heterologous expression of bacterial Rho factor in yeast interferes in normal mRNP biogenesis leading to the production of...

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Identifiers

PMID: 21113025
DOI: 10.1093/nar/gkq1192
PMCID: PMC3074134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Nuclear mRNA quality control in yeast is mediated by Nrd1 co-transcriptional recruitment, as revealed by the targeting of Rho-induced aberrant transcripts.PMID 21113025Read ↗

Nrd1p identifies aberrant and natural exosomal target messages during the nuclear mRNA surveillance in Saccharomyces cerevisiae.Semantic proximity Read ↗

Expression of bacterial Rho factor in yeast identifies new factors involved in the functional interplay between transcription and mRNP biogenesis.Semantic proximity Read ↗

Transcription termination and nuclear degradation of cryptic unstable transcripts: a role for the nrd1-nab3 pathway in genome surveillance.Semantic proximity Read ↗

A functional interface at the rDNA connects rRNA synthesis, pre-rRNA processing and nucleolar surveillance in budding yeast.Semantic proximity Read ↗

Insights into mRNP biogenesis provided by new genetic interactions among export and transcription factors.Semantic proximity Read ↗

An elevated level of the mRNA exporter Mex67-Mtr2 in nuclear mRNPs impairs nuclear mRNA exportSemantic proximity Read ↗

Structure and semi-sequence-specific RNA binding of Nrd1.Semantic proximity Read ↗

Proper 5'-3' cotranslational mRNA decay in yeast requires import of Xrn1 to the nucleus.Semantic proximity Read ↗

The RNA polymerase II C-terminal domain-interacting domain of yeast Nrd1 contributes to the choice of termination pathway and couples to RNA processing by the nuclear exosome.Semantic proximity Read ↗

The yeast hnRNP-like protein Hrp1/Nab4 marks a transcript for nonsense-mediated mRNA decay.Semantic proximity Read ↗

Yeast shuttling SR proteins Npl3p, Gbp2p, and Hrb1p are part of the translating mRNPs, and Npl3p can function as a translational repressor.Semantic proximity Read ↗

Genetic interactions of Hrd3p and Der3p/Hrd1p with Sec61p suggest a retro-translocation complex mediating protein transport for ER degradation.Semantic proximity Read ↗

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