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Article

Safety, immunogencity, and efficacy of a cold-adapted A/Ann Arbor/6/60 (H2N2) vaccine in mice and ferrets.

Virology - 1 Mar 2010

Chen Grace L, Lamirande Elaine W, Jin Hong, Kemble George, Subbarao Kanta

Abstract excerpt

We studied the attenuation, immunogenicity and efficacy of the cold-adapted A/Ann Arbor/6/60 (AA ca) (H2N2) virus in mice and ferrets to evaluate its use in the event of an H2 influenza pandemic. The AA ca virus was restricted in replication in the respiratory tract of mice and ferrets. In mice, 2 doses of vaccine elicited a >4-fold rise in hemagglutination-inhibition (HAI) titer and resulted in complete...

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Identifiers

PMID: 20034647
DOI: 10.1016/j.virol.2009.12.003
PMCID: PMC2823816

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