Back to search

Article

Sequential Immunization with Universal Live Attenuated Influenza Vaccine Candidates Protects Ferrets against a High-Dose Heterologous Virus Challenge

2018-12-27

Abstract excerpt

The development of universal influenza vaccines, i.e. vaccines that can provide broad protection against seasonal and potentially pandemic influenza viruses, has been a priority for more than 20 years. Several approaches have been proposed that redirect the adaptive immune responses from immunodominant hypervariable regions to low-immunogenic but highly conserved regions of viral proteins. Here we induced broadly...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
9412900e-d5e0-5a4f-9fe0-98c351288193
DOI
10.20944/preprints201812.0317.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Sequential Immunization with Universal Live Attenuated Influenza Vaccine Candidates Protects Ferrets against a High-Dose Heterologous Virus ChallengeDOI 10.20944/preprints201812.0317.v1
Sequential Immunization with Universal Live Attenuated Influenza Vaccine Candidates Protects Ferrets against a High-Dose Heterologous Virus ChallengeSemantic proximity
Development of Clade-Specific and Broadly Reactive Live Attenuated Influenza Virus Vaccines against Rapidly Evolving H5 Subtype Viruses.Semantic proximity
Truncation of NS1 Protein Enhances T Cell-Mediated Cross-Protection of a Live Attenuated Influenza Vaccine Virus Expressing Wild-Type NucleoproteinSemantic proximity
Immunization with Reverse‐Genetics–Produced H5N1 Influenza Vaccine Protects Ferrets against Homologous and Heterologous ChallengeSemantic proximity
Live, Attenuated Influenza A H5N1 Candidate Vaccines Provide Broad Cross-Protection in Mice and FerretsSemantic proximity
A One-Shot Multivalent Live-Attenuated Candidate Influenza Vaccine against Divergent Zoonotic H5N1 CladesSemantic proximity
Single- and multiple-clade influenza A H5N1 vaccines induce cross protection in ferretsSemantic proximity
Live attenuated influenza A virus vaccines with modified NS1 proteins for veterinary useSemantic proximity
A Single Dose of Inactivated Influenza Virus Vaccine Expressing COBRA Hemagglutinin Elicits Broadly-Reactive and Long-Lasting ProtectionSemantic proximity
Evaluation of Live Attenuated Influenza A Virus H6 Vaccines in Mice and FerretsSemantic proximity
Feasibility of reconstructed ancestral H5N1 influenza viruses for cross-clade protective vaccine developmentSemantic proximity
Digitally Immune-Optimised Next-Generation Influenza Vaccine Provides Cross-Clade Protection Against Emerging H5Nx VirusesSemantic proximity
Select a neighboring publication to make it the new centre.