Article
Regulation patterns in signaling networks of cancer.
BMC systems biology - 26 Nov 2010
Schramm Gunnar, Kannabiran Nandakumar, König Rainer
Abstract excerpt
BACKGROUND: Formation of cellular malignancy results from the disruption of fine tuned signaling homeostasis for proliferation, accompanied by mal-functional signals for differentiation, cell cycle and apoptosis. We wanted to observe central signaling characteristics on a global view of malignant cells which have evolved to selfishness and independence in comparison to their non-malignant counterparts that...
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