Article
Lesion-induced increase in nerve growth factor mRNA is mediated by c-fos.
Proceedings of the National Academy of Sciences of the United States of America - 1 May 1990
Hengerer B, Lindholm D, Heumann R, Rüther U, Wagner E F, Thoenen H
Abstract excerpt
Lesion of the sciatic nerve caused a rapid increase in c-fos and c-jun mRNA that was followed about 2 hr later by an increase in nerve growth factor (NGF) mRNA. To evaluate whether the initial increase in c-fos mRNA is causally related to the subsequent increase in NGF mRNA, we performed experime...
Topics
- Animals
- Base Sequence
- Binding Sites
- Cells, Cultured
- DNA-Binding Proteins
- Deoxyribonuclease I
- Fibroblasts
- Gene Expression
- Humans
- Kinetics
- Metallothionein
- Mice