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Article

Lesion-induced increase in nerve growth factor mRNA is mediated by c-fos.

Proceedings of the National Academy of Sciences of the United States of America - 1 May 1990

Hengerer B, Lindholm D, Heumann R, Rüther U, Wagner E F, Thoenen H

Abstract excerpt

Lesion of the sciatic nerve caused a rapid increase in c-fos and c-jun mRNA that was followed about 2 hr later by an increase in nerve growth factor (NGF) mRNA. To evaluate whether the initial increase in c-fos mRNA is causally related to the subsequent increase in NGF mRNA, we performed experiments with fibroblasts of transgenic mice carrying an exogenous c-fos gene under the control of a metallothionein...

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Identifiers

PMID: 2111020
DOI: 10.1073/pnas.87.10.3899
PMCID: PMC54011

Genes

NGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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