Article
Induction of c-fos, c-jun, junB and junD mRNA and AP-1 by alkylating mutagens in cells deficient and proficient for the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) and its relationship to cell death, mutation induction and chromosomal instability.
Oncogene - 7 Nov 1996
Dosch J, Kaina B
Abstract excerpt
An early and immediate response of cells upon irradiation with UV light and various other forms of genotoxic stress is the induction of the proto-oncogenes c-fos and c-jun. To address the questions of whether (a) methylating agents that are powerful carcinogens are effective in induction of fos a...
Topics
- Alkylating Agents
- Animals
- CHO Cells
- Cell Death
- Chromosome Aberrations
- Cricetinae
- DNA Repair
- Dose-Response Relationship, Drug
- Gene Expression Regulation, Neoplastic
- Glycoproteins
- Guanine
- Methyl Methanesulfonate
- Methylnitronitrosoguanidine
- Methyltransferases