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Temporal and spatial pattern of DNA damage in neurons following spinal cord Injury in mice

23 Jan 2025

Abstract excerpt

BACKGROUND: Deficient DNA repair and excessive DNA damage contribute to neurodegenerative disease. However, the role of DNA damage and repair in spinal cord injury (SCI) is unclear. SCI, a debilitating disruption of the structural and biological network of the spinal cord, is characterized by oxidative stress. Nevertheless, the pathophysiological mechanisms leading to neuronal loss following SCI remain...

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PMID: 39844195
DOI: 10.1186/s12929-024-01104-8

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