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Article

Anaplastic lymphoma kinase as a new target for the treatment of non-small-cell lung cancer

1 Nov 2011

Abstract excerpt

The anaplastic lymphoma kinase (ALK) gene rearrangement identifies a distinct molecular subset in non-small-cell lung cancer (NSCLC) populations susceptible to targeted inhibition. It consists of a small inversion in the short arm of chromosome 2 between exon 20 of the ALK gene and different exons of the echinoderm microtubule-associated protein-like (EML4) gene. This translocation leads to a chimeric protein...

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PMID: 22050016
DOI: 10.1586/era.11.157

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