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Native and rearranged ALK copy number and rearranged cell count in non–small cell lung cancer

10 Sept 2013

Abstract excerpt

BACKGROUND: Patients with anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) respond to ALK inhibitors. Clinically, the presence of ≥15% cells with rearrangements identified on break-apart fluorescence in situ hybridization (FISH) classifies tumors as positive. Increases in native and rearranged ALK copy number also occur. METHODS: In total, 1426 NSCLC clinical specimens (174...

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PMID: 24022839
DOI: 10.1002/cncr.28311

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