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Article

Polymorphisms in the ALOX12 gene and osteoporosis.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA - 1 Aug 2011

Harsløf T, Husted L B, Nyegaard M, Carstens M, Stenkjær L, Brixen K, Eiken P, Jensen J-E B, Børglum A D, Mosekilde L, Rejnmark L, Langdahl B L

Abstract excerpt

UNLABELLED: ALOX12 produces ligands for PPARγ thereby turning mesenchymal stem cells into adipocytes instead of osteoblasts. We investigated the effect of polymorphisms in the ALOX12 gene on BMD and fracture risk in two Danish cohorts and found four polymorphisms and a haplotype thereof to be associated with BMD and fracture risk. INTRODUCTION: Stimulation of the PPARγ with ligands produced by the ALOX enzymes...

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Source

Identifiers

PMID: 21104233
DOI: 10.1007/s00198-010-1472-2

Genes

ALOX12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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