ALOX12 gene polymorphisms and serum selenium status in elderly osteoporotic patients

Abstract excerpt

BACKGROUND: Osteoporosis is a systemic bone disease which leads to a reduction in bone mass. Many studies have shown that up to 80% of bone mineral density (BMD) variations are attributed to genetic factors. Arachidonate 12-lipoxygenase enzyme, encoded by the ALOX12 gene, produces lipid peroxides as reactive oxygen species (ROS), leading to oxidative stress and the development of osteoporosis. Selenium (Se) is...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bone health and osteoporosis research
• Share to Bone Metabolism and Diseases
• Share to Selenium in Biological Systems