Article
Amino acid residues that affect interaction of tissue-type plasminogen activator with plasminogen activator inhibitor 1.
Proceedings of the National Academy of Sciences of the United States of America - 1 May 1990
Madison E L, Goldsmith E J, Gerard R D, Gething M J, Sambrook J F, Bassel-Duby R S
Abstract excerpt
Fibrinolysis is regulated in part by the interaction between tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor 1 (PAI-1, a serine protease inhibitor of the serpin family). It is known from our earlier work that deletion of a loop of amino acids (residues 296-302) from t...
Topics
- Amino Acid Sequence
- Base Sequence
- Binding Sites
- Fibrinolysis
- Kinetics
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Plasminogen Inactivators
- Protein Binding
- Sequence Homology, Nucleic Acid
- Tissue Plasminogen Activator