Article
Analyses of native disulfide bond formations in the early stage of the folding process in mutant lysozymes where the long-range interactions in the denatured state were modulated.
Bioscience, biotechnology, and biochemistry - 1 Aug 2007
Mishima Tomonori, Ohkuri Takatoshi, Imoto Taiji, Ueda Tadashi
Abstract excerpt
In order to clarify whether modulation of long-range interactions in the denatured state affect native disulfide bond (SS bond) formations of hen egg white lysozyme (HEL) containing a pair of cysteine residues, we examined the extent of SS bond formation among 12 variants containing a pair of cysteines. The loss of clusters 5 and 6 in the denatured state affected the formation of Cys30-Cys115 and Cys6-Cys127...
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