Article
Pretreatment HIV drug resistance results in virological failure and accumulation of additional resistance mutations in Ugandan children.
The Journal of antimicrobial chemotherapy - 1 Sept 2017
Kityo Cissy, Boerma Ragna S, Sigaloff Kim C E, Kaudha Elizabeth, Calis Job C J, Musiime Victor, Balinda Sheila, Nakanjako Rita, Boender T Sonia, Mugyenyi Peter N, Rinke de Wit Tobias F
Abstract excerpt
Background: Pretreatment HIV drug resistance (PDR) can impair virological response to ART, jeopardizing effective treatment for children. Methods: Children aged ≤12 years initiated first-line ART in Uganda during 2010-11. Baseline and 6 monthly viral load (VL) and genotypic resistance testing if VL >1000 copies/mL was done. The 2015 IAS-USA mutation list and Stanford algorithm were used to score drug resistance...
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