Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Low Levels of Clinically Significant Drug Resistance Mutations to Dolutegravir Among Children Living with HIV Failing on First-Line Antiretroviral Therapy in Uganda.

Journal of acquired immune deficiency syndromes (1999) - 1 Feb 2026

Magongo Eleanor N, Hast Marisa, Nabitaka Vennie, Nakanwagi Miriam, Twinomujjuni Evarist, Dowling Stephanie, Senyama George, Nzano Brian, Alwano Mary, Nakaweesi Jane, Nazziwa Esther, Namayanja Grace, Nkolo Esther, Ayitewala Alisen, Hackett Stephanie

Abstract excerpt

BACKGROUND: Introduction of pediatric-friendly dolutegravir (DTG) formulations to treat children living with HIV (CLHIV) has presented new opportunities to improve viral suppression; however, there are limited data on emerging patterns of HIV drug resistance (HIVDR) in this population. METHODS: We identified CLHIV aged 0-15 years experiencing virologic failure on first-line antiretroviral therapy in Uganda...

Topics

Join the communities discussing this publication.

Anti-HIV Agents
Heterocyclic Compounds, 3-Ring
HIV Integrase Inhibitors
Oxazines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Treatment Failure

Source

Open in PubMed Open full text

Identifiers

PMID: 41129268
DOI: 10.1097/QAI.0000000000003784
PMCID: PMC12884821

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Low Levels of Clinically Significant Drug Resistance Mutations to Dolutegravir Among Children Living with HIV Failing on First-Line Antiretroviral Therapy in Uganda.PMID 41129268Read ↗

Pretreatment HIV drug resistance results in virological failure and accumulation of additional resistance mutations in Ugandan children.Semantic proximity Read ↗

Absence of HIV-1 Drug Resistance Mutations Supports the Use of Dolutegravir in Uganda.Semantic proximity Read ↗

Emerging integrase strand transfer inhibitor drug resistance mutations among children and adults on ART in Tanzania: findings from a national representative HIV drug resistance survey.Semantic proximity Read ↗

Short communication: high rates of thymidine analogue mutations and dual-class resistance among HIV-infected Ugandan children failing first-line antiretroviral therapy.Semantic proximity Read ↗

Prevalence of HIV drug resistance, its correlates and common mutations among people living with HIV failing on ART in northern Uganda: A cross-sectional study.Semantic proximity Read ↗

High frequency of HIV-1 drug resistance among individuals with persistent low-level viremia during first-line antiretroviral therapy in Uganda.Semantic proximity Read ↗

Prevalence of HIV drug resistance, its correlates and common mutations among people living with HIV failing on ART in northern Uganda. A cross-sectional studySemantic proximity Read ↗

High viral suppression and detection of dolutegravir-resistance associated mutations in treatment-experienced Tanzanian adults living with HIV-1 in Dar es Salaam.Semantic proximity Read ↗

Virological Findings and Treatment Outcomes of Cases That Developed Dolutegravir Resistance in Malawi’s National HIV Treatment ProgramSemantic proximity Read ↗

Pretreatment HIV drug resistance predicts accumulation of new mutations in ART-naïve Ugandan children.Semantic proximity Read ↗

HIV-1 drug resistance in people on dolutegravir-based ART: Collaborative analysis of cohort studiesSemantic proximity Read ↗

High Levels of Acquired HIV Drug Resistance Following Virological Nonsuppression in HIV-Infected Women from a High-Risk Cohort in Uganda.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.