Article
The in vitro contribution of autolysins to bacterial killing elicited by amoxicillin increases with inoculum size in Enterococcus faecalis.
Antimicrobial agents and chemotherapy - 1 Feb 2011
Dubée Vincent, Chau Françoise, Arthur Michel, Garry Louis, Benadda Samira, Mesnage Stéphane, Lefort Agnès, Fantin Bruno
Abstract excerpt
The mechanisms of antibiotic-induced cell death are poorly understood despite the critical role of the bactericidal activities of antibiotics for successful treatment of severe infections. These mechanisms include irreversible damaging of macromolecules by reactive oxygen species and bacteriolysis mediated by peptidoglycan hydrolases (autolysins). We have assessed the contribution of the second mechanism by using...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.