Article
Two bactericidal targets for penicillin in pneumococci: autolysis-dependent and autolysis-independent killing mechanisms.
Antimicrobial agents and chemotherapy - 1 Jan 1990
Moreillon P, Markiewicz Z, Nachman S, Tomasz A
Abstract excerpt
It has been assumed that penicillin (and also other cell wall inhibitors) kill pneumococci predominantly by triggering their major autolytic enzyme (an N-acetylmuramoyl-L-alanine amidase; referred to as amidase), resulting in massive cell wall degradation. Three types of experiments suggest that only part of this killing is due to cell lysis by amidase. (i) Suppression of penicillin-induced lysis by specific...
Topics
- Amidohydrolases
- Autolysis
- Culture Media
- Cycloserine
- DNA, Bacterial
- Hydrolases
- Indicators and Reagents
- Microbial Sensitivity Tests
- Mutation
- Penicillins
- RNA, Bacterial