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Article

Two bactericidal targets for penicillin in pneumococci: autolysis-dependent and autolysis-independent killing mechanisms.

Antimicrobial agents and chemotherapy - 1 Jan 1990

Moreillon P, Markiewicz Z, Nachman S, Tomasz A

Abstract excerpt

It has been assumed that penicillin (and also other cell wall inhibitors) kill pneumococci predominantly by triggering their major autolytic enzyme (an N-acetylmuramoyl-L-alanine amidase; referred to as amidase), resulting in massive cell wall degradation. Three types of experiments suggest that only part of this killing is due to cell lysis by amidase. (i) Suppression of penicillin-induced lysis by specific...

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Identifiers

PMID: 1691615
DOI: 10.1128/AAC.34.1.33
PMCID: PMC171516

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