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Demonstration of the role of cell wall homeostasis in Staphylococcus aureus growth and the action of bactericidal antibiotics

29 Oct 2021

Abstract excerpt

Significance The bacterial cell wall peptidoglycan is essential for maintenance of viability and yet is dynamic, permitting growth and division. Peptidoglycan synthesis is inhibited by important antibiotics, including β-lactams and vancomycin. Using the human pathogen Staphylococcus aureus , we have examined peptidoglycan homeostatic mechanisms and how their interruption leads to cell death. This has revealed two...

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PMID: 34716264
DOI: 10.1073/pnas.2106022118

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