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Article

Penicillin-binding proteins and the antibacterial effectiveness of beta-lactam antibiotics.

Reviews of infectious diseases - 1 Jan 2000

Tomasz A

Abstract excerpt

It is currently believed that both the antibacterial potency and the nature of the antibacterial effects of beta-lactam antibiotics are ultimately dependent on the inhibition (acylation) of one or more of the bacterial penicillin-binding proteins (PBPs). Nevertheless, bacterial factors (e.g., autolysins) that do not directly react with the antibiotic molecule also profoundly influence the fate (inhibition of...

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PMID: 3092301
DOI: 10.1093/clinids/8.supplement_3.s260

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