From penicillin-binding proteins to the lysis and death of bacteria: a 1979 view.

doi:10.1093/clinids/1.3.434

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Article

From penicillin-binding proteins to the lysis and death of bacteria: a 1979 view.

Reviews of infectious diseases - 1 Jan 2000

Tomasz A

Abstract excerpt

The mechanism by which interference with the biosynthesis of bacterial cell wall causes death and lysis of bacteria appears more complex than originally thought. In an earlier model of the mode of action of beta-lactams, it was assumed that, in the presence of the antibiotics, bacteria synthesize a mechanically weak (poorly cross-linked) cell wall that ruptured under the osmotic-mechanical pressure of the...

Topics

Animals
Bacteria
Bacterial Physiological Phenomena
Bacterial Proteins
Bacteriolysis
Carrier Proteins
Cell Division
Cell Wall
Escherichia coli
Hexosyltransferases
Humans
Hydrolases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Biological

Muramoylpentapeptide Carboxypeptidase

Mutation

N-Acetylmuramoyl-L-alanine Amidase

Penicillin Resistance

Penicillin-Binding Proteins

Source

Open in PubMed

Identifiers

PMID: 45147
DOI: 10.1093/clinids/1.3.434

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-45147-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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