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Article

MCP-1/CCR2B-dependent loop upregulates MUC5AC and MUC5B in human airway epithelium

20 Nov 2010

Abstract excerpt

Cigarette smoke represents a major risk factor for the development of chronic obstructive pulmonary disease (COPD), a respiratory condition associated with airflow obstruction, mucus hypersecretion, chronic inflammation, and upregulation of inflammatory mediators such as the monocyte chemotactic protein-1 (MCP-1). MCP-1 through its receptor CCR2 induces chemotaxis and activates (44/42)MAPK, a kinase known to play...

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PMID: 21097527
DOI: 10.1152/ajplung.00292.2010

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