Article
Relation between renal dysfunction requiring renal replacement therapy and promoter polymorphism of the erythropoietin gene in cardiac surgery.
Artificial organs - 1 Nov 2010
Popov Aron F, Schulz Egbert G, Schmitto Jan D, Coskun Kasim O, Tzvetkov Mladen V, Kazmaier Stephan, Zimmermann Janna, Schöndube Friedrich A, Quintel Michael, Hinz José
Abstract excerpt
Several genetic polymorphisms have been identified to play a role in the occurrence and progression of renal dysfunction after cardiac surgery with cardiopulmonary bypass (CPB). Recently, it was demonstrated that the T allele of SNP rs1617640 in the promoter of the erythropoetin (EPO) gene is significantly associated with proliferative diabetic retinopathy (PDR) and end-stage renal disease (ESRD) due to increased...
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