The Erythropoetin rs1617640 Gene Polymorphism Associates with Hemoglobin Levels, Hematocrit and Red Blood Cell Count in Patients with Peripheral Arterial Disease.

doi:10.3390/genes11111305

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The Erythropoetin rs1617640 Gene Polymorphism Associates with Hemoglobin Levels, Hematocrit and Red Blood Cell Count in Patients with Peripheral Arterial Disease.

Genes - 4 Nov 2020

Renner Wilfried, Kaiser Melanie, Khuen Sebastian, Trummer Olivia, Mangge Harald, Langsenlehner Tanja

Abstract excerpt

BACKGROUND: Erythropoietin has a pivotal role in erythropoiesis and angiogenesis. A common polymorphism (rs1617640, A > C) in the promoter of the erythropoietin gene (EPO) has been associated with erythropoietin expression and microvascular complications of diabetes. We aimed to analyze the potential role of this polymorphism in the pathogenesis of peripheral arterial disease (PAD). METHODS: EPO genotypes and...

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PMID: 33158076
DOI: 10.3390/genes11111305
PMCID: PMC7694227

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