Article
Galectin-8 tandem-repeat structure is essential for T-cell proliferation but not for co-stimulation.
The Biochemical journal - 15 Feb 2011
Cattaneo Valentina, Tribulatti María V, Campetella Oscar
Abstract excerpt
Gal (galectin)-8 is a tandem-repeat Gal containing N-CRDs (Nterminal carbohydrate-recognition domains) and C-CRDs (C-terminal carbohydrate-recognition domains) with differential glycan-binding specificity fused by a linker peptide. Gal-8 has two distinct effects on CD4 T-cells: at high concentrations it induces antigen-independent proliferation, whereas at low concentrations it co-stimulates antigen-specific...
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