Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Topological Arrangement of Cardiac Fibroblasts Regulates Cellular Plasticity.

Circulation research - 22 Jun 2018

Yu Jingyi, Seldin Marcus M, Fu Kai, Li Shen, Lam Larry, Wang Ping, Wang Yijie, Huang Dian, Nguyen Thang L, Wei Bowen, Kulkarni Rajan P, Di Carlo Dino, Teitell Michael, Pellegrini Matteo, Lusis Aldons J, Deb Arjun

Abstract excerpt

RATIONALE: Cardiac fibroblasts do not form a syncytium but reside in the interstitium between myocytes. This topological relationship between fibroblasts and myocytes is maintained throughout postnatal life until an acute myocardial injury occurs, when fibroblasts are recruited to, proliferate and aggregate in the region of myocyte necrosis. The accumulation or aggregation of fibroblasts in the area of injury...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Aggregation
Share to Cell Culture Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Plasticity

Share to Chromatin Assembly and Disassembly

Share to Culture Media, Conditioned

Share to Myocardial Infarction

Share to Myocardium

Share to Myocytes, Cardiac

Source

Open in PubMed Open full text

Identifiers

PMID: 29691232
DOI: 10.1161/CIRCRESAHA.118.312589
PMCID: PMC6014922

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Topological Arrangement of Cardiac Fibroblasts Regulates Cellular Plasticity.PMID 29691232Read ↗

Targeting Immune-Fibroblast Crosstalk in Myocardial Infarction and Cardiac FibrosisSemantic proximity Read ↗

The Role of Cardiac Fibroblast Heterogeneity in Myocardial Fibrosis and Its Novel Therapeutic PotentialSemantic proximity Read ↗

Integration mapping of cardiac fibroblast single-cell transcriptomes elucidates cellular principles of fibrosis in diverse pathologiesSemantic proximity Read ↗

Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injurySemantic proximity Read ↗

Integrative Single-Cell Analysis of Cardiomyopathy Identifies Differences in Cell Stemness and Transcriptional Regulatory Networks among Fibroblast SubpopulationsSemantic proximity Read ↗

Cardiac fibroblast sub-types in vitro reflect pathological cardiac remodeling in vivoSemantic proximity Read ↗

Spatio-temporal dynamics of the fibrotic niche in cardiac repairSemantic proximity Read ↗

Cell-cell interactions in the heart: advanced cardiac models and omics technologiesSemantic proximity Read ↗

Spatial imprints of emergent cardiomyocyte states in the pressure-overloaded heartSemantic proximity Read ↗

Cardiac Fibrosis and FibroblastsSemantic proximity Read ↗

Fibroblast polarization over the myocardial infarction time continuum shifts roles from inflammation to angiogenesisSemantic proximity Read ↗

Modeling cardiac fibroblast heterogeneity from human pluripotent stem cell-derived epicardial cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.