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Article

The yeast homolog of heme oxygenase-1 affords cellular antioxidant protection via the transcriptional regulation of known antioxidant genes.

The Journal of biological chemistry - 21 Jan 2011

Collinson Emma J, Wimmer-Kleikamp Sabine, Gerega Sebastien K, Yang Yee Hwa, Parish Christopher R, Dawes Ian W, Stocker Roland

Abstract excerpt

Heme oxygenase-1 (HO-1) degrades heme and protects cells from oxidative challenge. This antioxidant activity is thought to result from the HO-1 enzymatic activity, manifested by a decrease in the concentration of the pro-oxidant substrate heme, and an increase in the antioxidant product bilirubin...

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Identifiers

PMID: 21081499
DOI: 10.1074/jbc.M110.187062
PMCID: PMC3023516

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21081499-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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