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Article

AHR gene expression and the polymorphism rs2066853 are associated with clinicopathological parameters in colorectal carcinoma.

Human pathology - 1 Apr 2022

Cheng Tracie, Gamage Sujani Madhurika Kodagoda, Hewage Dinu, Lu Cu-Tai, Aktar Sharmin, Gopalan Vinod, Lam Alfred King-Yin

Abstract excerpt

The relationship between red and processed meat and its risk toward colorectal carcinoma (CRC) is not fully explored in literature. Polycyclic aromatic hydrocarbons (PAHs) are procarcinogenic molecules that are ingested with meat cooked at high temperatures. The metabolic conversion of PAHs to carcinogenic diol epoxides is in part mediated by the aryl hydrocarbon receptor (AhR)-dependent induction of CYP1A1. This...

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PMID: 35150736
DOI: 10.1016/j.humpath.2022.02.001

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