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Article

Core Transcription Factors Promote Induction of PAX3-Positive Skeletal Muscle Stem Cells

25 Jul 2019

Abstract excerpt

The use of adult skeletal muscle stem cells (MuSCs) for cell therapy has been attempted for decades, but still encounters considerable difficulties. MuSCs derived from human induced pluripotent stem cells (hiPSCs) are promising candidates for stem cell therapy to treat Duchenne muscular dystrophy (DMD). Here we report that four transcription factors, HEYL, KLF4, MYOD, and PAX3, selected by comprehensive screening...

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PMID: 31353225
DOI: 10.1016/j.stemcr.2019.06.006

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