Article
+9/+9 Homozygosity of the bradykinin receptor gene polymorphism is associated with reduced fat-free mass in chronic obstructive pulmonary disease.
The American journal of clinical nutrition - 1 Apr 2006
Hopkinson Nicholas S, Eleftheriou Kyriacos I, Payne John, Nickol Annabel H, Hawe Emma, Moxham John, Montgomery Hugh, Polkey Michael I
Abstract excerpt
BACKGROUND: The etiology of muscle wasting in chronic obstructive pulmonary disease (COPD) is incompletely understood. We previously showed that the D rather than the I polymorphic variant of the angiotensin-converting enzyme (ACE) gene is associated with preserved quadriceps strength in COPD. If the ACE D allele influences skeletal muscle through increased ACE-related kinin degradation [and reduced activity at...
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