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Article

Conditional meta-analysis stratifying on detailed HLA genotypes identifies a novel type 1 diabetes locus around TCF19 in the MHC.

Human genetics - 1 Feb 2011

Cheung Yee Him, Watkinson John, Anastassiou Dimitris

Abstract excerpt

The human leukocyte antigen (HLA) class II genes HLA-DRB1, -DQA1 and -DQB1 are the strongest genetic factors for type 1 diabetes (T1D). Additional loci in the major histocompatibility complex (MHC) are difficult to identify due to the region's high gene density and complex linkage disequilibrium (LD). To facilitate the association analysis, two novel algorithms were implemented in this study: one for phasing the...

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Identifiers

PMID: 21076979
DOI: 10.1007/s00439-010-0908-2
PMCID: PMC3020293

Genes

TCF19
CCHCR1

Provenance

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