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Article

SMAD7 and MGMT genotype variants and cancer incidence in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk Study.

Cancer epidemiology - 1 Aug 2011

Loh Yet Hua, Mitrou Panagiota N, Wood Angela, Luben Robert N, McTaggart Alison, Khaw Kay-Tee, Rodwell Sheila A

Abstract excerpt

PURPOSE: The SMAD7 gene was recently identified to be associated with colorectal cancer risk. Smad7 protein is a known inhibitor of TGF-β signalling pathway which has a prominent role in tumorigenesis. MGMT gene regulates the direct damage reversal repair pathway, preventing DNA damage and potential cancer development. This exploratory study aims to investigate the association between SMAD7 (rs4464148, rs4939827)...

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Source

Identifiers

PMID: 21075068
DOI: 10.1016/j.canep.2010.09.011

Genes

SMAD7
MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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