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Article

Functional analysis of the conserved hydrophobic gate region of the magnesium transporter CorA.

Biochimica et biophysica acta - 1 Jun 2011

Svidová Soňa, Sponder Gerhard, Schweyen Rudolf J, Djinović-Carugo Kristina

Abstract excerpt

The Leu294 residue in the cytoplasmic neck of Thermotoga maritima CorA is considered to be the main gate for Mg2+ transport. We created three site-directed mutants at this position: in the Leu294Asp and Leu294Gly mutants we observed a defect in closing of the pore, while in the Leu294Arg mutant not only gating, but also the regulation of Mg2+ uptake was affected. Our results confirmed the importance of the Leu294...

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Identifiers

PMID: 21074514
DOI: 10.1016/j.bbamem.2010.10.017
PMCID: PMC3082049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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