Article
Cation selectivity by the CorA Mg2+ channel requires a fully hydrated cation.
Biochemistry - 27 Jul 2010
Moomaw Andrea S, Maguire Michael E
Abstract excerpt
The CorA Mg(2+) channel is the primary uptake system in about half of all bacteria and archaea. However, the basis for its Mg(2+) selectivity is unknown. Previous data suggested that CorA binds a fully hydrated Mg(2+) ion, unlike other ion channels. The crystal structure of Thermotoga maritima CorA shows a homopentamer with two transmembrane segments per monomer connected by a short periplasmic loop. This highly...
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