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Article

Residues of a proposed gate region in type I ATP-binding cassette import systems are crucial for function as revealed by mutational analysis.

Biochimica et biophysica acta - 1 Sept 2013

Weidlich Daniela, Wiesemann Nicole, Heuveling Johanna, Wardelmann Kristina, Landmesser Heidi, Sani Katayoun Behnam, Worth Catherine L, Preissner Robert, Schneider Erwin

Abstract excerpt

The type I ATP-binding cassette (ABC) importer for positively charged amino acids of the thermophilic bacterium Geobacillus stearothermophilus consists of the extracellular solute binding protein, ArtJ, and a homodimer each of the transmembrane subunit, ArtM, and the nucleotide-binding and -hydrolyzing subunit, ArtP. We have investigated the functional consequences of mutations affecting conserved residues from...

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PMID: 23747295
DOI: 10.1016/j.bbamem.2013.05.032

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