Article
Methods for investigating gene-environment interactions in candidate pathway and genome-wide association studies.
Annual review of public health - 1 Jan 2010
Thomas Duncan
Abstract excerpt
Despite the considerable enthusiasm about the yield of novel and replicated discoveries of genetic associations from the new generation of genome-wide association studies (GWAS), the proportion of the heritability of most complex diseases that have been studied to date remains small. Some of this "dark matter" could be due to gene-environment (G x E) interactions or more complex pathways involving multiple genes...
Topics
- Bayes Theorem
- Environmental Exposure
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Models, Theoretical
- Public Health
- Research Design