Article
Autophosphorylation activates Dictyostelium myosin II heavy chain kinase A by providing a ligand for an allosteric binding site in the alpha-kinase domain.
The Journal of biological chemistry - 28 Jan 2011
Crawley Scott W, Gharaei Mojdeh Samimi, Ye Qilu, Yang Yidai, Raveh Barak, London Nir, Schueler-Furman Ora, Jia Zongchao, Côté Graham P
Abstract excerpt
Dictyostelium discoideum myosin II heavy chain kinase A (MHCK A), a member of the atypical α-kinase family, phosphorylates sites in the myosin II tail that block filament assembly. Here we show that the catalytic activity of A-CAT, the α-kinase domain of MHCK A (residues 552-841), is severely inhibited by the removal of a disordered C-terminal tail sequence (C-tail; residues 806-841). The key residue in the...
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