Article
Conditional loss-of-myosin-II-function mutants reveal a position in the tail that is critical for filament nucleation.
Molecular cell - 1 Jun 1998
Moores S L, Spudich J A
Abstract excerpt
Myosin-II must be assembled into filaments to perform its cellular functions. Two conditional loss-of-myosin-II-function mutants were recovered from a previous genetic screen with defects that were mapped to the coiled-coil tail region of Dictyostelium myosin-II. Strikingly, both tail mutations affected the same arginine residue at position 1880. A single amino acid substitution, R1880P, disrupted both the...
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