Conditional loss-of-myosin-II-function mutants reveal a position in the tail that is critical for filament nucleation.

doi:10.1016/s1097-2765(00)80104-5

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Article

Conditional loss-of-myosin-II-function mutants reveal a position in the tail that is critical for filament nucleation.

Molecular cell - 1 Jun 1998

Moores S L, Spudich J A

Abstract excerpt

Myosin-II must be assembled into filaments to perform its cellular functions. Two conditional loss-of-myosin-II-function mutants were recovered from a previous genetic screen with defects that were mapped to the coiled-coil tail region of Dictyostelium myosin-II. Strikingly, both tail mutations a...

Topics

Actin Cytoskeleton
Amino Acid Substitution
Amino Acids
Animals
Arginine
Dictyostelium
Dimerization
Mutation
Myosin Heavy Chains
Myosin Subfragments
Myosins
Phosphorylation
Proline
Threonine

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