Article
Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease.
Journal of neuroinflammation - 23 Aug 2009
Combarros Onofre, van Duijn Cornelia M, Hammond Naomi, Belbin Olivia, Arias-Vásquez Alejandro, Cortina-Borja Mario, Lehmann Michael G, Aulchenko Yurii S, Schuur Maaike, Kölsch Heike, Heun Reinhard, Wilcock Gordon K, Brown Kristelle, Kehoe Patrick G, Harrison Rachel, Coto Eliecer, Alvarez Victoria, Deloukas Panos, Mateo Ignacio, Gwilliam Rhian, Morgan Kevin, Warden Donald R, Smith A David, Lehmann Donald J
Abstract excerpt
BACKGROUND: Chronic inflammation is a characteristic of Alzheimer's disease (AD). An interaction associated with the risk of AD has been reported between polymorphisms in the regulatory regions of the genes for the pro-inflammatory cytokine, interleukin-6 (IL-6, gene: IL6), and the anti-inflammatory cytokine, interleukin-10 (IL-10, gene: IL10). METHODS: We examined this interaction in the Epistasis Project, a...
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