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Article

Population- and family-based studies associate the MTHFR gene with idiopathic autism in simplex families.

Journal of autism and developmental disorders - 1 Jul 2011

Liu Xudong, Solehdin Fatima, Cohen Ira L, Gonzalez Maripaz G, Jenkins Edmund C, Lewis M E Suzanne, Holden Jeanette J A

Abstract excerpt

Two methylenetetrahydrofolate reductase gene (MTHFR) functional polymorphisms were studied in 205 North American simplex (SPX) and 307 multiplex (MPX) families having one or more children with an autism spectrum disorder. Case-control comparisons revealed a significantly higher frequency of the low-activity 677T allele, higher prevalence of the 677TT genotype and higher frequencies of the 677T-1298A haplotype and...

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Source

Identifiers

PMID: 21069446
DOI: 10.1007/s10803-010-1120-x

Genes

MTHFR
SPX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Population- and family-based studies associate the MTHFR gene with idiopathic autism in simplex families.PMID 21069446Read ↗

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Association of methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism with autism: evidence of genetic susceptibility.Semantic proximity Read ↗

The MTHFR 677C-->T polymorphism and behaviors in children with autism: exploratory genotype-phenotype correlations.Semantic proximity Read ↗

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