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Article

Population- and family-based studies associate the MTHFR gene with idiopathic autism in simplex families.

Journal of autism and developmental disorders - 1 Jul 2011

Liu Xudong, Solehdin Fatima, Cohen Ira L, Gonzalez Maripaz G, Jenkins Edmund C, Lewis M E Suzanne, Holden Jeanette J A

Abstract excerpt

Two methylenetetrahydrofolate reductase gene (MTHFR) functional polymorphisms were studied in 205 North American simplex (SPX) and 307 multiplex (MPX) families having one or more children with an autism spectrum disorder. Case-control comparisons revealed a significantly higher frequency of the l...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21069446
DOI: 10.1007/s10803-010-1120-x

Genes

MTHFR
SPX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21069446-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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