Article
The MTHFR 677C-->T polymorphism and behaviors in children with autism: exploratory genotype-phenotype correlations.
Autism research : official journal of the International Society for Autism Research - 1 Apr 2009
Goin-Kochel Robin P, Porter Anne E, Peters Sarika U, Shinawi Marwan, Sahoo Trilochan, Beaudet Arthur L
Abstract excerpt
New evidence suggests that autism may be associated with (a) varied behavioral responses to folate therapy and (b) metabolic anomalies, including those in folate metabolism, that contribute to hypomethylation of DNA. We hypothesized that children with autism who are homozygous for the MTHFR 677 T allele (TT) and, to a lesser extent those with the CT variant, would exhibit more behavioral problems and/or more...
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