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Article

RNA editing changes the lesion specificity for the DNA repair enzyme NEIL1.

Proceedings of the National Academy of Sciences of the United States of America - 30 Nov 2010

Yeo Jongchan, Goodman Rena A, Schirle Nicole T, David Sheila S, Beal Peter A

Abstract excerpt

Editing of the pre-mRNA for the DNA repair enzyme NEIL1 causes a lysine to arginine change in the lesion recognition loop of the protein. The two forms of NEIL1 are shown here to have distinct enzymatic properties. The edited form removes thymine glycol from duplex DNA 30 times more slowly than t...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21068368
DOI: 10.1073/pnas.1009231107
PMCID: PMC2996456

Genes

NEIL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21068368-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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