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Adnectins: engineered target-binding protein therapeutics

10 Nov 2010

Abstract excerpt

Adnectins™ are a new family of therapeutic proteins based on the 10th fibronectin type III domain, and designed to bind with high affinity and specificity to therapeutically relevant targets. Adnectins share with antibody variable domains a beta-sheet sandwich fold with diversified loops, but differ from antibodies in primary sequence and have a simpler, single-domain structure without disulfide bonds. As a...

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PMID: 21068165
DOI: 10.1093/protein/gzq097

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