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Selection and Characterization of Her2 Binding-designed Ankyrin Repeat Proteins

9 Sept 2006

Abstract excerpt

Designed ankyrin repeat proteins (DARPins) are a novel class of binding proteins that bind their target protein with high affinity and specificity and have very favorable expression and stability properties. We describe here the in vitro selection of DARPins against human epidermal growth factor receptor 2 (Her2), an important target for cancer therapy and diagnosis. Several DARPins bind to the same epitope as...

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PMID: 16963452
DOI: 10.1074/jbc.m602547200

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