Mammalian Target of Rapamycin–Dependent Acinar Cell Neoplasia after Inactivation of <i>Apc</i> and <i>Pten</i> in the Mouse Salivary Gland: Implications for Human Acinic Cell Carcinoma

Abstract excerpt

Cross-talk between the canonical Wnt and mammalian target of rapamycin (mTOR) signaling pathways occurs at multiple levels in the cell and likely contributes to the oncogenic effects of these pathways in human cancer. To gain more insight into the interplay between Wnt and mTOR signaling in salivary gland tumorigenesis, we developed a mouse model in which both pathways are constitutively activated by the...

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