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Article

Transforming somatic mutations of mammalian target of rapamycin kinase in human cancer.

Cancer science - 1 Dec 2015

Yamaguchi Hiroyuki, Kawazu Masahito, Yasuda Takahiko, Soda Manabu, Ueno Toshihide, Kojima Shinya, Yashiro Masakazu, Yoshino Ichiro, Ishikawa Yuichi, Sai Eirin, Mano Hiroyuki

Abstract excerpt

Mammalian target of rapamycin (mTOR) is a serine-threonine kinase that acts downstream of the phosphatidylinositol 3-kinase signaling pathway and regulates a wide range of cellular functions including transcription, translation, proliferation, apoptosis, and autophagy. Whereas genetic alterations that result in mTOR activation are frequently present in human cancers, whether the mTOR gene itself becomes an...

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Source

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Identifiers

PMID: 26432419
DOI: 10.1111/cas.12828
PMCID: PMC4714661

Genes

ATM
TRRAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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