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Article

Ablation of interleukin-19 improves motor function in a mouse model of amyotrophic lateral sclerosis.

Molecular brain - 30 Apr 2021

Komiya Hiroyasu, Takeuchi Hideyuki, Ogawa Yuki, Suzuki Kosuke, Ogasawara Akihiro, Takahashi Keita, Azuma Yasu-Taka, Doi Hiroshi, Tanaka Fumiaki

Abstract excerpt

Neuroinflammation by activated microglia and astrocytes plays a critical role in progression of amyotrophic lateral sclerosis (ALS). Interleukin-19 (IL-19) is a negative-feedback regulator that limits pro-inflammatory responses of microglia in an autocrine and paracrine manner, but it remains unclear how IL-19 contributes to ALS pathogenesis. We investigated the role of IL-19 in ALS using transgenic mice carrying...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33931083
DOI: 10.1186/s13041-021-00785-8
PMCID: PMC8086093

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