Article
Current treatment concepts of Philadelphia-negative MPN.
Current cancer drug targets - 1 Jan 2011
Wolf D, Rudzki J, Gastl G
Abstract excerpt
Since William Dameshek has described the concept of "myeloproliferative disorders (MPD)" by identifying common clinical characteristics (i.e. hemorrhage, thrombosis and leukemic transformation) of polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), the advent of molecular biology has provided substantial molecular insight into the pathobiology of myeloproliferative neoplasia...
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