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Philadelphia Chromosome–Negative Myeloproliferative Disorders: Biology and Treatment

1 Jan 2007

Abstract excerpt

The Philadelphia chromosome (Ph)-negative myeloproliferative disorders (MPDs) include essential thrombocythemia (ET), idiopathic myelofibrosis (IMF), and polycythemia vera (PV). All of these disorders are clonal hematologic malignancies originating at the level of the pluripotent hematopoietic stem cell. Recently, activating mutations of the intracellular cytokine-signaling molecule JAK2 have been identified in >...

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PMID: 17222772
DOI: 10.1016/j.bbmt.2006.11.003

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