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Article

Current approaches to challenging scenarios in myeloproliferative neoplasms.

Expert review of anticancer therapy - 1 Jun 2018

Zimran Eran, Hoffman Ronald, Kremyanskaya Marina

Abstract excerpt

INTRODUCTION: The Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) including polycythemia vera, essential thrombocythemia and primary myelofibrosis are clonal hematological malignancies that originate at the level of the hematopoietic stem cell, and are characterized by excessive proliferation of cells belonging to one or more of the myeloid lineages. Central to the pathogenesis of the MPNs is...

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Identifiers

PMID: 29575945
DOI: 10.1080/14737140.2018.1457441

Genes

CALR
JAK2
MPL

Provenance

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