Article
C reactive protein and chronic obstructive pulmonary disease: a Mendelian randomisation approach.
Thorax - 1 Mar 2011
Dahl Morten, Vestbo Jørgen, Zacho Jeppe, Lange Peter, Tybjærg-Hansen Anne, Nordestgaard Børge G
Abstract excerpt
BACKGROUND: It is unclear whether elevated plasma C reactive protein (CRP) is causally related to chronic obstructive pulmonary disease (COPD). The authors tested the hypothesis that genetically elevated plasma CRP causes COPD using a Mendelian randomisation design. METHODS: The authors measured high-sensitivity CRP in plasma, genotyped for four single nucleotide polymorphisms in the CRP gene, and screened for...
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